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  SPECIFICATION
ESSENTIALS IN HEMATOLOGY AND CLINICAL PATHOLOGY (pb)2012
Author: RAMADAS NAYAK
ISBN: 9789350255995
Year: 2012
Publisher: JAYPEE BROTHERS MEDICAL PUBLISHERS PVT LTD.
Category: PATHOLOGY
Edition: 1
Format: Paperback
Language: English
Pages: 575
 ABOUT THE TITLE
Richly illustrated easy to understand and student friendly book. Contemporary concepts on hematological diseases. Highly illustrated in multicolor. Helpful and detailed more than 146 tables. Text enhanced by 135 illustrations, 27 photomicrographs and 18 photographs. Molecular basis of common hematological disorders. Laboratory findings of diseases presented in simplified manner.

Authors: Ramadas Nayak/ Sharada Rai and Astha Gupta
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 TABLE OF CONTENTS
SECTION 1: Disorders of Red Cells
1. INTRODUCTION 3
• Hematopoiesis 4
2. CLASSIFICATION OF ANEMIA 10
• Red cell 10
• Anemia 11
3. IRON DEFICIENCY ANEMIA 15
• Iron Metabolism 15
• Iron Deficiency Anemia 18
4. MEGALOBLASTIC ANEMIA 26
• Metabolism of Vitamin B12 and Folic Acid 27
• Etiology of Megaloblastic Anemia 31
• Laboratory Findings of Megaloblastic Anemia 31
• Anemias of Vitamin B12 Deficiency 36
• Anemia of Folate Deficiency 40
• Nonmegaloblastic Causes of Macrocytic Anemias 41
5. INTRODUCTION AND CLASSIFICATION OF HEMOLYTIC ANEMIA 45
• Hemolytic Anemia 47
• Classification of Hemolytic Anemias 53
6. HEMOLYTIC ANEMIAS DUE TO RED CELL MEMBRANE DISORDERS 57
• Hereditary Spherocytosis 58
• Hereditary Elliptocytosis 61
7. THALASSEMIA SYNDROMES 63
• ß-Thalassemia 64
• a-Thalassemia 70
8. SICKLE CELL DISEASE 75
• Sickle Cell Anemia 76
• Sickle Cell Trait 84
• Other Sickling Syndromes 85
• Other Hemoglobinopathies 86
9. HEMOLYTIC ANEMIAS DUE TO RED CELL ENZYME DEFICIENCIES 89
• Metabolic Pathways in Red Blood Cells 89
• Glucose-6-phosphate Dehydrogenase Deficiency 89
• Pyruvate Kinase Deficiency 94
10. IMMUNOHEMOLYTIC ANEMIA 96
• Alloimmune Hemolytic Anemia 97
• Autoimmune Hemolytic Anemia 99
11. FRAGMENTATION SYNDROME 106
• Laboratory Findings 107
12. PAROXYSMAL NOCTURNAL HEMOGLOBINURIA 109
• Etiology and Pathogenesis 109
• Clinical Features 110
• Laboratory Findings 111
13. APPROACH TO HEMOLYTIC ANEMIAS 113
14. APLASTIC ANEMIA 115
• Etiology 115
• Pathogenesis 116
• Clinical Features 118
• Laboratory Findings 118
15. PURE RED CELL APLASIA 121
• Etiology 121
• Clinical Features 121
• Laboratory Findings 122
16. MISCELLANEOUS RBC DISORDERS 123
• Anemia of Chronic Disease 123
• Anemia of Renal Disease 125
• Anemia of Liver Disease 125
• Anemias of Blood Loss 125
• Anemia Associated with Marrow Infiltration 126
17. SIDEROBLASTIC ANEMIA 128
• Hereditary Sideroblastic Anemias 129
• Acquired Idiopathic Sideroblastic Anemia 130
• Congenital Dyserythropoietic Anemias 130
18. POLYCYTHEMIA 132
• Polycythemia Vera 133
SECTION 2: Disorders of White Cells
19. QUANTITATIVE AND QUALITATIVE DISORDERS OF WHITE BLOOD CELLS 139
• Classification of WBC Disorders 142
• Quantitative Disorders of Leukocytes 142
• Qualitative Disorders of Leukocytes 149
20. INFECTIOUS MONONUCLEOSIS 152
• Pathogenesis 152
• Clinical Features 154
• Laboratory Findings 154
• Lesions Associated with EBV Infection 156
21. INTRODUCTION TO ACUTE LEUKEMIA 158
• Neoplastic Proliferations of White Cells 158
• Acute Leukemia 159
22. ACUTE LYMPHOBLASTIC LEUKEMIA 170
• Acute Lymphoblastic Leukemia 170
• Acute Lymphoblastic Lymphoma 174
23. ACUTE MYELOGENOUS LEUKEMIA AND RELATED NEOPLASM 176
• Acute Myelogenous Leukemia 176
• Myeloid Sarcoma 179
24. MYELODYSPLASTIC SYNDROMES 181
• Etiology and Molecular Pathogenesis 182
• Clinical Features 183
• Laboratory Findings 183
25. MYELOPROLIFERATIVE NEOPLASM 186
• Essential Thrombocythemia 187
• Primary Myelofibrosis 188
26. CHRONIC MYELOGENOUS LEUKEMIA AND OTHER MYELOID NEOPLASMS 191
• Chronic Myelogenous Leukemia 191
• Myelodysplastic/Myeloproliferative Neoplasms 198
27. CHRONIC LYMPHOCYTIC LEUKEMIA AND OTHER LYMPHOID LEUKEMIAS 201
• Chronic Lymphocytic Leukemia 201
• Prolymphocytic Leukemia 205
• Hairy Cell Leukemia 206
28. PLASMA CELL NEOPLASMS 210
• Plasma Cell Myeloma 211
• Plasmacytoma 220
• Immunoglobulin Deposition Diseases 220
• Monoclonal Gammopathy of Uncertain Significance 221
• Osteosclerotic Myeloma 221
29. LYMPHOPOIETIC SYSTEM 224
• Lymph Nodes 224
• Development of Lymphocytes 226
30. LYMPHOID NEOPLASMS 232
• Classification of Lymphoid Neoplasms 232
• Precursor Lymphoid Neoplasms 234
• Mature B cell Neoplasms 234
• Mature T cell and NK cell Neoplasms 246
31. HODGKIN LYMPHOMA 254
• Classical Hodgkin Lymphoma 258
• Nodular Lymphocyte Predominant Hodgkin Lymphoma 264
• Etiology and Pathogenesis of Hodgkin Lymphoma 265
• Laboratory Findings 267
• Clinical Features 268
32. LANGERHANS CELL HISTIOCYTOSIS 272
• Morphology 272
• Laboratory Findings 273
SECTION 3: Disorders of Hemostasis
33. NORMAL HEMOSTASIS AND ITS COMPONENTS 277
• Platelets 277
• Blood Vessel Wall 278
• Coagulation System 279
• Coagulation Regulatory Mechanism 281
• Fibrinolytic System 284
• Normal Hemostasis 284
34. BLEEDING DISORDERS: VESSEL WALL ABNORMALITIES 289
• Disorders of Hemostasis 289
• Bleeding Disorders Caused by Vessel Wall Abnormalities 292
35. BLEEDING DISORDERS: ABNORMALITIES OF PLATELET 296
• Quantitative Platelet Disorders 296
• Qualitative Platelet Disorders 307
36. BLEEDING DISORDERS: ABNORMALITIES OF COAGULATION FACTORS 312
• Hereditary Deficiencies 313
• Acquired Coagulation Disorders 318
• Disseminated Intravascular Coagulation 319
37. THROMBOTIC DISORDERS: HYPERCOAGULABLE STATES 326
• Inherited Hypercoagulable States 327
• Acquired Hypercoagulable States 328
SECTION 4: Clinical Pathology
38. ANTICOAGULANTS AND COLLECTION OF BLOOD 335
• Anticoagulants 335
• Steps in Hematological Investigation 337
39. HEMATOPOIESIS 343
• Erythropoiesis 343
• Myelopoiesis 345
• Megakaryopoiesis 346
40. HEMOGLOBIN ESTIMATION 350
• Methods of Hemoglobin Estimation 350
• Colorimetric Methods 350
• Other Methods 357
41. CELL COUNT 359
• Red Blood Cell Count 360
• Total WBC Count 363
• Platelet Count 366
• Absolute Eosinophil Count 368
42. PERIPHERAL BLOOD SMEAR EXAMINATION 371
• Stains for Blood Smear 371
• Preparation of the Peripheral Blood Smear 372
Contents xvii
• Fixation of the Smear 373
• Staining of the Smear 373
• Examination of a Peripheral Blood Smear 374
• Red Blood Cells 375
• White Blood Cells 378
• Platelets 380
• Hemoparasites 380
43. RETICULOCYTE COUNT 386
• Methods of Reticulocyte Count 386
• Significance of Reticulocyte Count 388
44. HEMATOCRIT, RED CELL INDICES AND ESR ESTIMATION 390
• Hematocrit 390
• Red Cell Indices 393
• Erythrocyte Sedimentation Rate 395
• LE Cell Test 398
45. BONE MARROW EXAMINATION 402
• Bone Marrow Aspiration 402
• Bone Marrow Trephine Biopsy 405
46. OSMOTIC FRAGILITY TEST 407
• Principle 407
• Procedure 408
• Interpretation 408
47. CYTOCHEMISTRY IN LEUKEMIA 411
• Myeloperoxidase 411
• Sudan Black B 412
• Nonspecific Esterase 412
• Periodic Acid Schiff Reaction 412
• Neutrophil Alkaline Phosphatase 413
48. LABORATORY EVALUATION OF HEMOSTATIC AND THROMBOTIC DISORDERS 415
• Tests for Platelet Component 416
• Tests for Platelet and Vascular Component 417
• Tests for Coagulation Component 419
• Tests for Fibrinolytic Activity 423
49. FLOW CYTOMETRY 426
• Applications of Flow Cytometry 428
50. URINE ANALYSIS 430
• Physical Examination 430
• Chemical Examination 435
• Microscopic Examination 451
51. BODY FLUIDS 459
• Examination of Body Fluids 460
• Examination of Synovial Fluids 461
52. CEREBROSPINAL FLUID EXAMINATION 464
• Examination of CSF 466
xviii Essentials in Hematology and Clinical Pathology
53. SEMEN ANALYSIS 469
• Different Procedures of Semen Analysis 469
• Cryopreservation of Spermatozoa 476
54. PREGNANCY TEST 478
• Pregnancy Tests 478
55. SPUTUM EXAMINATION 482
• Examination of Sputum 482
56. CYTOLOGY 485
• Cytology of Female Genital Tract 488
• Cytology of Other Systems 491
• Buccal Smear for Barr Body 491
• FNAC Appearance of some Common Lesions 492
57. GLUCOSE TOLERANCE TEST 496
• Oral Glucose Tolerance Test 496
• Glycosuria 498
58. BLOOD GROUP SYSTEM 500
• ABO Blood Group System 500
• Rh Blood Group System 505
• Other Blood Group Systems 506
59. ANTIGLOBULIN TEST 508
• Direct Antiglobulin Test 508
• Indirect Antiglobulin Test 510
60. TRANSFUSION MEDICINE 512
• Blood Transfusion 512
• Blood Components 515
• Transfusion Reactions 517
61. HEMATOPOIETIC STEM CELL TRANSPLANTATION 522
• Autologous Stem Cell Transplant 523
• Allogeneic Stem Cell Transplantation 524
• Complications of HSC Transplantation 525
62. GASTRIC FUNCTION TESTS 527
• Tests for Gastric Acid Secretion 527
• Other Tests 528
63. LIVER FUNCTION TESTS AND LIVER BIOPSY 530
• Liver Function Tests 530
• Liver Biopsy 537
64. RENAL FUNCTION TESTS 541
• Tests For Renal Function 541
• Renal Biopsy 543
65. THYROID FUNCTION TESTS 545
• Thyroid Function Tests 546
Appendix 551
Bibliography ..557
Index 559
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